Drug Discovery and Development Services

Our World-Class Services

Aryastha offers cutting-edge services and alliances, leveraging our advanced
technology platform and comprehensive capabilities across the drug discovery
process. With a distinguished track record, experienced scientists, and an
innovative approach, we set ourselves apart in the industry.
Drug Development Services

Integrated Drug Discovery

Integrated drug discovery services encompass a range of offerings designed to bolster and expedite drug development while cutting down the time and expenses required for introducing new drugs. The drug discovery process is intricate and demanding, spanning various phases such as target identification, lead discovery, optimization, preclinical, and clinical development. These comprehensive services excel in identifying potential challenges at an early stage of drug development, thereby contributing to cost savings by mitigating the expenses linked to unsuccessful drug development initiatives.

Discovery Services

Drug Development Services

Discovery Chemistry

Medicinal chemistry within the realm of drug discovery involves the intricate process of conceiving and developing new medicines. While this journey is lengthy, complex, expensive, and risky, the potential benefits for millions of patients with serious illnesses serve as a constant driving force. Central to this effort is medicinal chemistry, a discipline that meticulously selects and crafts compounds. These compounds establish critical structure-activity relationships (SARs), ensuring efficacy and safety through preclinical in vitro, ex vivo
and in vivo models.

Drug Development Services

Discovery Biology

Aryastha Lifesciences specializes in drug discovery and development services, harnessing the power of established cells, primary cells from diseased organs, and In- vivo models, including syngeneic and cell/tissue-derived systems. Our seamless integration of In- vitro biology, In- vivo pharmacology, and DMPK services offers robust support for drug discovery and early development endeavors. This integration and our expertise in discovery chemistry, CMC, and safety assessment enable us to successfully generate preclinical candidates and deliver comprehensive IND packages.

Drug Development Services

Pre-Clinical DMPK

Aryastha provides a comprehensive range of services encompassing in vitro ADME, toxicity (in vitro ADMET), and in vivo pharmacokinetics (PK), offering rapid evaluations of test articles DMPK properties and toxicity. Our team specializes in crafting robust DMPK packages tailored for submissions to regulatory agencies like FDA, MHRA and GLP.

Transitioning from Research to Development

Integrated drug discovery services encompass a range of offerings designed to bolster and expedite drug development while cutting down the time and expenses required for introducing new drugs. The drug discovery process is intricate and demanding, spanning various phases such as target identification, lead discovery, optimization, preclinical, and clinical development. These comprehensive services excel in identifying potential challenges at an early stage of drug development, thereby contributing to cost savings by mitigating the expenses linked to unsuccessful drug development initiatives.

Development Services

Drug Development Services

Process Chemistry Services

Our dedicated process chemistry team is committed to aiding you in route scouting and crafting a process tailored to your project's needs. This process guarantees safety, reproducibility, robustness, and superior quality. All our process development endeavors are guided by Quality by Design (QbD) principles, integrating analytical and risk-management methodologies throughout molecule design, development, and manufacturing stages.

Drug Development Services

Route Exploration and Process Development

The process begins with designing the route, which involves conducting retrosynthetic analysis, practical evaluation for yield enhancement, and ensuring safety through thorough thermodynamic studies. This leads to route investigation, encompassing in-depth exploration of potential routes and method development. The process is developed, optimizing both early and late-stage processes, employing strategically designed experiments (DoE), and troubleshooting reactions.

Drug Development Services

Tailored Scale-Up Solutions

Navigating the transition from preclinical to commercial-scale manufacturing brings intricate challenges and intricacies. Our custom scale-up service encompasses in-house production ranging from hundreds of grams to kilograms of non-GMP material, serving demo batches, proof of principle, and preclinical studies. Seamlessly transferring technology to larger scales and ensuring GMP-compliant manufacturing is a pivotal aspect of our offering.

Medicinal Chemistry and Drug Discovery

Analytical Solutions

Leveraging a wealth of experience, our analytical specialists expedite the transformation of your molecule from conception to clinical stages and beyond with unwavering success. Complemented by abundant capacity and diverse analytical insight, we provide our clients unparalleled access to a team of genuine problem solvers well-versed in the entire product life cycle. With an arsenal of cutting-edge analytical and synthetic equipment, we excel in conducting meticulous impurity identification for drug substances.

Medicinal Chemistry and Drug Discovery

Route Scouting

Pioneering Efficiency Route scouting is foundational in identifying a safe, efficient, and cost-effective synthesis process for large-scale production. Key questions encompass safety considerations, raw material availability and affordability, patent implications, intermediate stability, purification methods, environmental concerns, and alternative routes derived from thorough literature reviews. Regulatory compliance is also weighed, shaping decisions that optimize time, cost, and quality. Our approach integrates these crucial aspects to formulate an optimized route.

Medicinal Chemistry and Drug Discovery

Analytical Suppport

Our integrated analytical support entails method development and synthesizing and purifying analytical standards to empower accurate analysis and quality assessment.

Our proficiency extends across diverse domains, encompassing

Integrated Drug Discovery Services
Integrated Drug Discovery Services

Our Impurity Identification Solutions Encompass

Therepeutic Areas

Integrated Drug Discovery Services

Oncology

Our oncology services offer advanced techniques including cancer cell panel screening, cell proliferation studies (CellTiter Glo), 3D culture assays, apoptosis analysis, and target validation (shRNA, RNAi, Crispr-Cas9). Additionally, we provide characterization of cell/animal models through whole exome and RNAseq analyses. Our comprehensive approach enables significant progress in cancer research.
Integrated Drug Discovery Services

Metabolic Disorder

In the realm of metabolic disorder research, our services encompass GSIS (Intact islet/pancreatic beta cell) assessments, fatty acid synthesis and oxidation assays, TCA cycle evaluations, glucose uptake studies, and the detection of TG, glycogen, and ketone bodies. Our comprehensive capabilities facilitate insightful discoveries in the field of metabolic disorders.
Integrated Drug Discovery Services

Immunology

Our immunology services encompass diverse techniques, including cytokine/chemokine profiling, T cell activation/proliferation, B cell and NK cell activation, ADCC, and immune cell co-culture with tumor cells. We specialize in PD1/PD-L1 binding assays, immune checkpoint evaluations, and immune reporter cells. Our offerings extend to engineered cel

Contact Us

India

Aryastha Life Sciences Private Limited, ARx,
Synergy Square II, Genome Valley, Shameerpet, Hyderabad,
500078, India

+91 91547 82433

USA

Aryastha Life Sciences, Inc.
One Broadway, 14th Floor
Cambridge, MA 02142