Extensive cancer cell lines and tumor bank
CDX models and PDX models with access to human tumor samples through a local hospitals
Syngeneic models with immune profiles, SOC data, and orthotopic imaging models encompassing hundreds of human and murine cancer cell lines
Metabolic models, obesity, diabetes, NAFLD & NASH
Cardiovascular diseases (MCAO, SHR, cardiac ischemia/reperfusion, hyperlipidemia)
Organ damage diseases models (CKD)
Respiratory disease models (lung inflammation and fibrosis)
Acute and chronic pain models
Immune disease models and non-immune inflammatory models
Arthritis, visceral pain, surgery pain, neuropathic pain models, and PD/PK models
Ex vitro analysis confirms the In vitro effects of test articles and establishes the correlation between efficacy, target engagement and biomarkers. All samples utilized in ex vitro analysis are derived from animals involved in the study, encompassing blood, plasma, cerebrospinal fluid (CSF), various body fluids, tissue extractions, urine, and feces.
PK/PD studies play a pivotal role in validating the exposure of the test article and biomarker levels within the systemic circulation and tissues, with a particular focus on target organs.
