Discovery Biology

We use established cell lines from ATCC or other reputed organizations. These lines are very early passages free from common contamination like microplasma. This is mainly used for understanding the molecular pathway perturbation using developmental molecules in a high-throughput manner.

These cells are mainly derived from diseased tissues (rodents and humans). These cells provide more biologically relevant data than that established cell lines. At Aryastha, we have developed a faster way to generate primary cells of our interest, and these cells can be used in various applications, from basic research to drug discovery. These lines are combined with 3D cell culture technologies for better reagents/models to improve research. These cells are ethically sourced and authenticated by testing possible contamination and key disease-specific markers.

Here are disease indications of different species (mice and humans) for our primary cell’s capabilities. Tumor cells (Breast, Lungs, GBM, CRC, HNSCC, Ovarian, etc.), Immune Cells (microphases, dendritic cells), Heart, Liver, and Kidney Cells.

We have generated and developed primary cells-derived mouse models for oncology and non-oncology drug discovery- for efficacy, pharmacodynamic, and biomarker studies. We also use established cell lines derive murine model for PK/PD/Efficacy correlation. We have also developed syngeneic mouse models for drug discovery and development where both tumor/immune microenvironments are preserved. We offer different in vitro and in vivo models mimicking the biology of human/rodent diseases. We use them to understand the biology, pathway perturbation, PK, and its correlation with target inhibition, efficacy, and meaningful understanding of possible biomarkers.