ORGANOIDS
- 3D cell-derived structures that mimic architecture and function of real organs.
- Derived from stem cells or patient tissues.
- Self-organize into physiologically relevant systems
WHY ORGANOIDS MATTER
- More physiologically relevant than 2D cell lines.
- Bridge between in vitro studies, animal models, and clinical trials
- Enable personalized medicine through patient-derived models
PATIENT DERIVED TUMOR ORGANOIDS
“Harnessing self-organization to model complexity and predict therapy response”
COLORECTAL CANCER (CRC) ORGANOIDS DEVELOPED AT ARYASTHA
CRC ORGANOIDS DEVELOPED AT ARYASTHA FAITHFULLY MIMIC PARENT TUMOR
- A: Morphological evaluation by H&E.
- B: Label free bright-field (BF) microscopic examination.
- C: Immunohistochemical profiling of proliferation (Ki67), viability (Caspase3c) and epithelial integrity (Pan-CK) markers from PFA fixed organoid blocks. Image magnification: 4x, 10x, 20x.
