Discovery & Pre-Clinical DMPK
Aryastha provides a comprehensive range of services encompassing in vitro ADME, toxicity (in vitro ADMET), and in vivo pharmacokinetics (PK), offering rapid evaluations of test articles DMPK properties and toxicity. Our team specializes in crafting robust DMPK packages tailored for submissions to regulatory agencies like FDA, MHRA and GLP.
In vitro ADMET
In vitro ADME (Absorption, Distribution, Metabolism, and Excretion) studies are a cornerstone of early-stage drug development. These assays are conducted outside of living organisms—typically in test tubes, petri dishes, or cell cultures—to predict how a drug behaves in the human body.
Pharmacokinetics
It is a fundamental aspect of drug discovery and development, focusing on how a drug behaves inside a living organism. These studies provide real-world data on absorption, distribution, metabolism, and excretion (ADME), helping researchers understand the drug’s fate and optimize its therapeutic potential.
Bioanalysis
Bioanalysis studies are a critical part of drug screening and development, focusing on the quantitative measurement of drugs and their metabolites in biological matrices such as blood, plasma, urine, and tissues. These studies support pharmacokinetic (PK), pharmacodynamic (PD), toxicokinetic, and bioequivalence evaluations, which are essential for understanding a drug’s behaviour in the body.
